No toxicity level has been indicated. Since niacin is a water-soluble vitamin, the body eliminates excesses through the urine.
As I've indicated, however, with massive doses there can be permanent damage to the liver, digestive tract or sex hormones: that is why the strict guidance of a physician and follow-up tests are necessary for administering megadoses. Overdosing will frequently happen to patients who need to have their blood cholesterol reduced to lessen what appears to be symptoms of schizophrenia but are really symptoms of subclinical pellagra, misdiagnosed as schizophrenia.
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