This midpoint structure can indicate an ailment involving total transformation of the bone, cell or blood structure—a transformation that may manifest when a progressed planet hits the midpoint. Progressed Admetos to the midpoint may suggest the start of an undetected disease that may take several years to become apparent. Progressed Hades on the midpoint may indicate a health crisis and a possible worsening of a health condition. Endocrine problems involving the adrenal or parathyroid glands are also possible.

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